MOTS-c
Mitochondrial-derived peptide discussed for experimental roles in metabolic regulation, insulin sensitivity, and cellular stress responses.
This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.
Overview
MOTS-c is a mitochondrial-derived peptide that has been studied in preclinical and early translational research for potential impacts on metabolism, insulin sensitivity, and cellular stress responses.
It is not part of standard care for metabolic disease.
Mechanism of action
Experimental work suggests that MOTS-c can influence pathways related to AMPK activation, glucose utilization, and mitochondrial function.
These findings are largely derived from animal models and cell studies.
Indications and use context
Interest in MOTS-c centers on metabolic and age-related conditions, but any potential therapeutic roles remain investigational.
Catalog listing reflects research and wellness discussions rather than guideline-based indications.
Safety and side effects
Human safety data for MOTS-c are limited. Most information comes from preclinical models.
Long-term effects of directly modulating mitochondrial pathways in humans are not fully understood.
Pharmacology and dosing considerations
MOTS-c is an exercise-mimetic peptide. It is known for causing injection site pain.
Route: Subcutaneous injection.
Protocol structure and dosage:- Dosage: 5 mg to 10 mg per administration.
- Frequency: Once weekly or up to 3 times weekly.
- Note: Injection can cause a stinging sensation and localized reaction (welts) lasting hours or days.
This information summarizes commonly discussed research practices.
Formulations and combinations
MOTS-c typically appears as an injectable peptide and may be grouped with other mitochondrial or metabolic modulators in catalogs.
Research and evidence snapshot
Studies have explored MOTS-c in metabolic syndrome models, aging-related pathways, and exercise physiology, focusing on surrogate markers more than long-term clinical outcomes.
Frequently asked questions
Future FAQs may discuss how mitochondrial peptides like MOTS-c relate to established metabolic treatments and lifestyle interventions. Answers will remain educational and non-prescriptive.
Sport & Anti-Doping Warning
MOTS-c is a mitochondrial-derived peptide that has drawn attention from anti-doping regulators as a potential metabolic modulator; it was added to the WADA Prohibited List under the section for metabolic and gene modulators.
Because MOTS-c targets core metabolic pathways, anti-doping agencies treat it similarly to other S4 metabolic modulators.
Comments
Loading comments...
Get the Standard Protocols.
Join 12,000+ researchers. Receive weekly breakdowns of new compounds, safety data updates, and source verification reports.