Glutathione

Endogenous tripeptide antioxidant sometimes administered parenterally or orally in wellness and hepatology contexts, with varying evidence and regulatory perspectives.

Educational only

This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.

Overview

Glutathione is an endogenous tripeptide (glutamate, cysteine, glycine) that plays a central role in intracellular redox balance and detoxification.

Exogenous glutathione is sometimes administered in wellness, hepatology, and dermatology contexts, though practice and evidence differ by region.

Mechanism of action

Glutathione participates in antioxidant defenses, conjugation of certain xenobiotics, and maintenance of other antioxidant systems.

Indications and use context

Potential roles have been studied in liver disease, oxidative stress states, and cosmetic skin-lightening, among others. Only some of these uses may be supported or approved in specific settings.

Safety and side effects

High-level safety themes

Safety depends on route of administration, dose, and underlying conditions.

Parenteral products require attention to sterility, excipients, and infusion reactions. Cosmetic or wellness uses may not have the same level of evidence or regulatory oversight as labeled medical indications.

Pharmacology and dosing considerations

Glutathione has poor oral bioavailability, leading to a preference for parenteral or liposomal administration in therapeutic settings.

Common administration patterns
Injectable (Systemic):
  • Route: Intravenous (IV) push/drip or Intramuscular (IM).
  • Dosage: 600 mg to 2000 mg per administration.
  • Frequency: 1–3 times weekly.
Oral (Liposomal):
  • Dosage: 500 mg to 1000 mg daily.

This information summarizes commonly discussed practices. IV administration is often combined with Vitamin C to prevent oxidation.

Formulations and combinations

Glutathione is available as injectable solutions, oral capsules, and sometimes as part of compounded "drip" blends with vitamins and other agents.

Combination products should be evaluated for compatibility, indication, and cumulative risk.

Research and evidence snapshot

Evidence spans basic science, small clinical trials, and cosmetic reports. Findings are context-specific and do not support broad claims of detoxification or anti-aging.

Frequently asked questions

Future FAQs may address how glutathione supplementation compares with supporting endogenous antioxidant systems through lifestyle and established therapies. Answers will remain educational and non-prescriptive.

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