GHK-CU
Copper-binding tripeptide used in cosmetic and regenerative settings for skin and hair, with emerging but heterogeneous evidence.
This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.
Overview
GHK-CU is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) complexed with copper. It appears in cosmetic, dermatologic, and regenerative discussions for its potential effects on skin and hair.
Mechanism of action
Proposed actions include modulation of wound healing pathways, collagen and glycosaminoglycan synthesis, and support of extracellular matrix remodeling.
Copper plays roles in angiogenesis and enzyme function, but systemic copper handling must also be considered.
Indications and use context
GHK-CU is most often used or studied in topical products and procedures targeting photoaging, scars, or hair density. In some settings it is also compounded in injectable forms.
Safety and side effects
Topical use is generally focused on local skin tolerance. Parenteral or high-dose systemic exposure raises additional theoretical concerns about copper balance.
Pharmacology and dosing considerations
GHK-Cu is versatile, appearing in topicals and injectables. Dosing varies significantly by method.
- Route: Subcutaneous or Intramuscular.
- Dosage: 1 mg to 2 mg daily or every other day.
- Note: Can be painful at injection site; often diluted further or rotated.
- Concentration: Typically 1% to 2% in serums or creams.
- Application: Daily application to affected areas.
This information summarizes commonly discussed practices. Injectable GHK-Cu is notable for potential injection site pain ("sting").
Formulations and combinations
GHK-CU appears in serums, creams, microneedling cocktails, and injectable preparations, often combined with other peptides, vitamins, or growth factors.
Research and evidence snapshot
Evidence includes in vitro work and human studies of varying size and design, primarily in aesthetic contexts. Outcomes emphasize appearance and subjective assessments more than hard medical endpoints.
Frequently asked questions
Future FAQs may compare GHK-CU-based approaches to other skin and hair treatments and discuss how patients and clinicians weigh cost, convenience, and evidence. Answers will remain educational and non-prescriptive.
Comments
Loading comments...
Get the Standard Protocols.
Join 12,000+ researchers. Receive weekly breakdowns of new compounds, safety data updates, and source verification reports.