5-Amino-1MQ

Small-molecule NNMT inhibitor discussed in experimental metabolic and weight-related research settings, with a limited and early-stage evidence base.

Educational only

This page is for general educational and informational purposes only. It is not medical advice and does not replace professional medical judgment. Always consult a qualified clinician before starting, stopping, or changing any medication or protocol.

Overview

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in methylation pathways and nicotinamide metabolism.

It is sometimes discussed in experimental metabolic and weight-related research contexts, but it is not an established therapy in major clinical guidelines.

Mechanism of action

NNMT catalyzes the methylation of nicotinamide, influencing pools of nicotinamide and related metabolites that intersect with cellular energy and redox pathways.

By inhibiting NNMT, 5-amino-1MQ is hypothesized to shift energy balance and metabolic signaling in adipose and other tissues. Most of this work comes from preclinical and early mechanistic studies.

Indications and use context

Discussions of 5-amino-1MQ often focus on potential roles in obesity, insulin resistance, or other metabolic conditions. At present, these ideas are largely investigational.

In many jurisdictions, 5-amino-1MQ does not have formal therapeutic indications and may only appear in research or non-regulated markets.

Safety and side effects

High-level safety themes

Safety data for 5-amino-1MQ in humans are limited, and long-term effects of sustained NNMT inhibition are not fully understood.

As with any experimental agent that interacts with core metabolic pathways, potential concerns include off-target metabolic effects and interactions with other medications or comorbid conditions.

Pharmacology and dosing considerations

5-Amino-1MQ is an oral small molecule NNMT inhibitor, distinct from injectable peptides.

Common administration patterns

Route: Oral (Capsules).

Protocol structure and dosage:
  • Dosage: 50 mg to 150 mg daily.
  • Frequency: Taken once daily or divided into two doses.
  • Timing: Often taken with food to improve absorption and reduce potential GI upset.

This information summarizes commonly discussed research practices.

Formulations and combinations

In catalogs, 5-amino-1MQ may appear as capsules or other oral preparations, sometimes discussed alongside peptides and small molecules with metabolic or weight-related themes.

Listing alongside other agents does not imply endorsement of combination regimens or stacked protocols.

Research and evidence snapshot

Published work on 5-amino-1MQ includes mechanistic and animal studies examining weight, adiposity, and metabolic markers, with limited early clinical data, if any, in humans.

Extrapolating these findings to real-world outcomes requires caution and careful review of primary sources.

Frequently asked questions

Future FAQs may address how NNMT inhibition fits conceptually within the broader landscape of metabolic therapies, how it compares to lifestyle and established pharmacologic options, and what evidence thresholds would be needed for routine use. Answers will remain educational and non-prescriptive.

Sport & Anti-Doping Warning

5-amino-1MQ is a small-molecule NNMT inhibitor marketed in some wellness and physique circles; as an unapproved drug, it falls into the general S0 category of non-approved substances under the World Anti-Doping Code.

Advisory Note

Even when not named explicitly on the Prohibited List, experimental metabolic drugs like 5-amino-1MQ are captured by the S0 'non-approved substance' rule.

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